Vitamin C is dispensable for oxygen sensing in vivo

Prolyl-4-hydroxylation is necessary for proper structural assembly of collagens and oxygen-dependent protein stability of hypoxia-inducible transcription factors (HIFs). In vitro function of HIF prolyl-4-hydroxylase domain (PHD) enzymes requires oxygen and 2-oxoglutarate as cosubstrates with iron(II...

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Bibliografiske detaljer
Main Authors: Nytko, Katarzyna J., Maeda, Nobuyo, Schläfli, Philipp, Spielmann, Patrick, Wenger, Roland H., Stiehl, Daniel P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2011
Fag:
Red Cells, Iron, and Erythropoiesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109719/
https://ncbi.nlm.nih.gov/pubmed/21346252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-307637
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