PXR Prevents Cholesterol Gallstone Disease by Regulating Biosynthesis and Transport of Bile Salts

BACKGROUND & AIMS: Cholesterol gallstone disease (CGD) results from a biochemical imbalance of lipids and bile salts in the gallbladder bile. We investigated whether the xenobiotic receptor pregnane X receptor (PXR) has a role in pathogenesis of CGD. METHODS: Wild-type, PXR-null (PXR-/-), and CG...

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Huvudupphovsmän: He, Jinhan, Nishida, Shigeru, Xu, Meishu, Makishima, Makoto, Xie, Wen
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109201/
https://ncbi.nlm.nih.gov/pubmed/21354151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.02.055
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