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PXR Prevents Cholesterol Gallstone Disease by Regulating Biosynthesis and Transport of Bile Salts
BACKGROUND & AIMS: Cholesterol gallstone disease (CGD) results from a biochemical imbalance of lipids and bile salts in the gallbladder bile. We investigated whether the xenobiotic receptor pregnane X receptor (PXR) has a role in pathogenesis of CGD. METHODS: Wild-type, PXR-null (PXR-/-), and CG...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3109201/ https://ncbi.nlm.nih.gov/pubmed/21354151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.02.055 |
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