Ex Vivo γ-Retroviral Gene Therapy of Dogs with X-linked Severe Combined Immunodeficiency and the Development of a Thymic T Cell Lymphoma

We have previously shown that in vivo γ-retroviral gene therapy of dogs with X-linked severe combined immunodeficiency (XSCID) results in sustained T cell reconstitution and sustained marking in myeloid and B cells for up to 4 years with no evidence of any serious adverse effects. The purpose of thi...

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Main Authors: Kennedy, Douglas R., Hartnett, Brian J., Kennedy, Jeffrey S., Vernau, William, Moore, Peter F., O’Malley, Thomas, Burkly, Linda C., Henthorn, Paula S., Felsburg, Peter J.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109141/
https://ncbi.nlm.nih.gov/pubmed/21536334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vetimm.2011.04.003
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