Dopamine-Derived Biological Reactive Intermediates and Protein Modifications: Implications for Parkinson’s Disease

Dopamine (DA) undergoes monoamine oxidase catalyzed oxidative deamination to 3,4-dihydroxyphenylacetaldehyde (DOPAL), which is metabolized primarily to 3,4-dihydroxyphenylacetic acid (DOPAC) via aldehyde dehydrogenase (ALDH). Previous studies demonstrated DOPAL to be neurotoxic, more so than DA and...

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Detalhes bibliográficos
Main Authors: Jinsmaa, Yunden, Florang, Virginia R., Rees, Jennifer N., Mexas, Lydia M., Eckert, Laurie L., Allen, Erin M.G., Anderson, David G., Doorn, Jonathan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3109112/
https://ncbi.nlm.nih.gov/pubmed/21238438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2011.01.006
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