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Inhibition of Mdm2 Sensitizes Human Retinal Pigment Epithelial Cells to Apoptosis
PURPOSE. Because recent studies indicate that blocking the interaction between p53 and Mdm2 results in the nongenotoxic activation of p53, the authors sought to investigate whether the inhibition of p53-Mdm2 binding activates p53 and sensitizes human retinal epithelial cells to apoptosis. METHODS. A...
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| Main Authors: | , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Association for Research in Vision and Ophthalmology, Inc.
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3109032/ https://ncbi.nlm.nih.gov/pubmed/21345989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-6991 |
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