HPLC-UV, MALDI-TOF-MS and ESI-MS/MS Analysis of the Mechlorethamine DNA Crosslink at a Cytosine-Cytosine Mismatch Pair

BACKGROUND: Mechlorethamine [ClCH(2)CH(2)N(CH(3))CH(2)CH(2)Cl], a nitrogen mustard alkylating agent, has been proven to form a DNA interstrand crosslink at a cytosine-cytosine (C-C) mismatch pair using gel electrophoresis. However, the atomic connectivity of this unusual crosslink is unknown. METHOD...

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Main Authors: Rojsitthisak, Pornchai, Jongaroonngamsang, Nutthapon, Romero, Rebecca M., Haworth, Ian S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108972/
https://ncbi.nlm.nih.gov/pubmed/21673963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020745
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