Defective angiogenesis in hypoplastic human fetal lungs correlates with nitric oxide synthase deficiency that occurs despite enhanced angiopoietin-2 and VEGF

Lung hypoplasia (LH) is a life-threatening congenital abnormality with various causes. It involves vascular bed underdevelopment with abnormal arterial muscularisation leading to pulmonary hypertension. Because underlying molecular changes are imperfectly known and sometimes controversial, we determ...

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Main Authors: Boucherat, Olivier, Franco-Montoya, Marie-Laure, Delacourt, Christophe, Martinovic, Jelena, Masse, Virginie, Elie, Caroline, Thebaud, Bernard, Benachi, Alexandra, Bourbon, Jacques R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108964/
https://ncbi.nlm.nih.gov/pubmed/20348277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00333.2009
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