Opposing cardiac effects of autoantibody activation of beta-adrenergic and M2 muscarinic receptors in cardiac-related diseases

BACKGROUND: Activating autoantibodies to β-adrenergic receptors (AAβ1/2AR) and M2 muscarinic receptors (AAM2R) have been reported in several cardiac diseases and may have pathophysiologic relevance. However, the interactions and relative effects of AAβ1AR, AAβ2AR and AAM2R on contractile function ha...

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Main Authors: Stavrakis, Stavros, Kem, David C., Patterson, Eugene, Lozano, Pedro, Huang, Shijun, Szabo, Bela, Cunningham, Madeleine W., Lazzara, Ralph, Yu, Xichun
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108570/
https://ncbi.nlm.nih.gov/pubmed/20053466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcard.2009.11.025
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