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Angiotensin II blockade upregulates the expression of Klotho, the anti-ageing gene, in an experimental model of chronic cyclosporine nephropathy

Background. The Klotho gene plays a role in suppressing ageing-related disorders. It is suggested that activation of renin–angiotensin system (RAS) or oxidative stress suppresses Klotho in the kidney. This study evaluated the association between Klotho expression and RAS in cyclosporine (CsA)-induce...

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Detalhes bibliográficos
Main Authors: Yoon, Hye Eun, Ghee, Jung Yeon, Piao, ShangGuo, Song, Ji-Hyun, Han, Dong He, Kim, Sol, Ohashi, Naro, Kobori, Hiroyuki, Kuro-o, Makoto, Yang, Chul Woo
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108350/
https://ncbi.nlm.nih.gov/pubmed/20813770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ndt/gfq537
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