Tetherin does not significantly restrict dendritic cell-mediated HIV-1 transmission and its expression is upregulated by newly synthesized HIV-1 Nef

BACKGROUND: Dendritic cells (DCs) are among the first cells to encounter HIV-1 and play important roles in viral transmission and pathogenesis. Immature DCs allow productive HIV-1 replication and long-term viral dissemination. The pro-inflammatory factor lipopolysaccharide (LPS) induces DC maturatio...

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Bibliographic Details
Main Authors: Coleman, Christopher M, Spearman, Paul, Wu, Li
Format: Artigo
Language:Inglês
Published: BioMed Central 2011
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108291/
https://ncbi.nlm.nih.gov/pubmed/21504576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-8-26
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