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Doxorubicin loaded pH-sensitive micelle targeting acidic extracellular pH of human ovarian A2780 tumor in mice

The purpose of this study was to examine the efficacy of a chemotherapeutic drug, doxorubicin (DOX), loaded in pH-sensitive micelles poly(l-histidine) (M(n):5K)-b-PEG (M(n):5K) micelles. The micelles were designed to target the acidic extracellular pH of solid tumors. Studies of pH-dependent cytotox...

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Hlavní autoři: GAO, Z.G., LEE, D.H., KIM, D.I., BAE, Y.H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2005
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3108254/
https://ncbi.nlm.nih.gov/pubmed/16308207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10611860500376741
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