Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT(2C) receptors

Muscle paralysis after spinal cord injury is partly caused by a loss of brainstem-derived serotonin (5-HT), which normally maintains motoneuron excitability by regulating crucial persistent calcium currents. Here we examine how over time motoneurons compensate for lost 5-HT to regain excitability. W...

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Detalhes bibliográficos
Main Authors: Murray, Katherine C, Nakae, Aya, Stephens, Marilee J, Rank, Michelle, D'Amico, Jessica, Harvey, Philip J, Li, Xiaole, Harris, R Luke W, Ballou, Edward W, Anelli, Roberta, Heckman, Charles J, Mashimo, Takashi, Vavrek, Romana, Sanelli, Leo, Gorassini, Monica A, Bennett, David J, Fouad, Karim
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107820/
https://ncbi.nlm.nih.gov/pubmed/20512126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2160
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