Rescue of Targeted Regions of Mammalian Chromosomes by in Vivo Recombination in Yeast

In contrast to other animal cell lines, the chicken pre-B cell lymphoma line, DT40, exhibits a high level of homologous recombination, which can be exploited to generate site-specific alterations in defined target genes or regions. In addition, the ability to generate human/chicken monochromosomal h...

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Autores principales: Kouprina, Natalya, Kawamoto, Kensaku, Barrett, J. Carl, Larionov, Vladimir, Koi, Minoru
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 1998
Materias:
Genome Methods
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC310736/
https://ncbi.nlm.nih.gov/pubmed/9647640
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