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Two-phase dynamics of p53 in the DNA damage response
The tumor suppressor p53 mainly induces cell cycle arrest/DNA repair or apoptosis in the DNA damage response. How to choose between these two outcomes is not fully understood. We proposed a four-module model of the p53 signaling network and associated the network dynamics with cellular outcomes afte...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107314/ https://ncbi.nlm.nih.gov/pubmed/21576488 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100600108 |
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