Optimized clinical performance of growth hormone with an expanded genetic code

The ribosomal incorporation of nonnative amino acids into polypeptides in living cells provides the opportunity to endow therapeutic proteins with unique pharmacological properties. We report here the first clinical study of a biosynthetic protein produced using an expanded genetic code. Incorporati...

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Библиографические подробности
Главные авторы: Cho, Ho, Daniel, Tom, Buechler, Ying Ji, Litzinger, David C., Maio, Zhenwei, Putnam, Anna-Maria Hays, Kraynov, Vadim S., Sim, Bee-Cheng, Bussell, Stuart, Javahishvili, Tsotne, Kaphle, Sami, Viramontes, Guillermo, Ong, Mike, Chu, Stephanie, GC, Becky, Lieu, Ricky, Knudsen, Nick, Castiglioni, Paola, Norman, Thea C., Axelrod, Douglas W., Hoffman, Andrew R., Schultz, Peter G., DiMarchi, Richard D., Kimmel, Bruce E.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2011
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107295/
https://ncbi.nlm.nih.gov/pubmed/21576502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100387108
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