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Control of Toxoplasma reactivation by rescue of dysfunctional CD8(+) T-cell response via PD-1–PDL-1 blockade
In this study, we document that Toxoplasma gondii differentiation and reactivation are mediated by systemic CD8 T-cell dysfunction during chronic infection. We demonstrate that CD8(+) T-cell exhaustion occurs despite control of parasitemia during early-chronic toxoplasmosis. During later phases, the...
Sparad:
| Huvudupphovsmän: | , , , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2011
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3107287/ https://ncbi.nlm.nih.gov/pubmed/21576466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015298108 |
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