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Chk2 and p53 Are Haploinsufficient with Dependent and Independent Functions to Eliminate Cells after Telomere Loss

The mechanisms that cells use to monitor telomere integrity, and the array of responses that may be induced, are not fully defined. To date there have been no studies in animals describing the ability of cells to survive and contribute to adult organs following telomere loss. We developed assays to...

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Bibliografski detalji
Glavni autori: Kurzhals, Rebeccah L., Titen, Simon W. A., Xie, Heng B., Golic, Kent G.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107200/
https://ncbi.nlm.nih.gov/pubmed/21655087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002103
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