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An efficient oxidative dearomatization–radical cyclization approach to symmetrically substituted bicyclic guttiferone natural products

Detailed in this communication is an efficient synthetic approach towards the guttiferone family of natural products. Oxidatively unraveling a para-quinone monoketal followed by consecutive 5-exo radical cyclizations provides the bicyclic core. An additional strength of this approach is a late stage...

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Detalhes bibliográficos
Main Authors: McGrath, Nicholas A., Binner, Joshua R., Markopoulos, Georgios, Brichacek, Matthew, Njardarson, Jon T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107033/
https://ncbi.nlm.nih.gov/pubmed/20607196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0cc01419b
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