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Novel functions of the α-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer’s disease

Measures in autopsied brains from Alzheimer’s Disease (AD) patients reveal a decrease in the activity of α-ketoglutarate dehydrogenase complex (KGDHC) and an increase in malate dehydrogenase (MDH) activity. The present experiments tested whether both changes could be caused by the common oxidant H(2...

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Bibliografiske detaljer
Main Authors: Shi, Qingli, Xu, Hui, Kleinman, Wayne A., Gibson, Gary E.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3106300/
https://ncbi.nlm.nih.gov/pubmed/18206986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2007.12.008
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