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Transgenic α-1-antitrypsin secreted into the bloodstream from salivary glands is biologically active

OBJECTIVES: Salivary glands are potentially a valuable target for gene therapeutics. Herein, we examined the expression and biochemical activity of human alpha-1-antitrypsin (hA1AT) produced in rodent submandibular glands after gene transfer. METHODS: A serotype 5 adenoviral vector (Ad.hA1AT) was co...

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Detalhes bibliográficos
Main Authors: Perez, Paola, Adriaansen, Janik, Goldsmith, Corinne M., Zheng, Changyu, Baum, Bruce J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3106112/
https://ncbi.nlm.nih.gov/pubmed/21122036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1601-0825.2010.01775.x
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