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Transgenic α-1-antitrypsin secreted into the bloodstream from salivary glands is biologically active
OBJECTIVES: Salivary glands are potentially a valuable target for gene therapeutics. Herein, we examined the expression and biochemical activity of human alpha-1-antitrypsin (hA1AT) produced in rodent submandibular glands after gene transfer. METHODS: A serotype 5 adenoviral vector (Ad.hA1AT) was co...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3106112/ https://ncbi.nlm.nih.gov/pubmed/21122036 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1601-0825.2010.01775.x |
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