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DNA Damage Responses in Progeroid Syndromes Arising from Defective Maturation of Prelamin A
The genetic diseases Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) arise from accumulation of farnesylated prelamin A due to defects in the lamin A maturation pathway. Both of these diseases exhibit symptoms which can be viewed as accelerated aging. The mechanism by whi...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2006
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3105909/ https://ncbi.nlm.nih.gov/pubmed/17062639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.03263 |
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