CDKN1B, encoding the cyclin-dependent kinase inhibitor 1B (p27), is located in the minimally deleted region of 12p abnormalities in myeloid malignancies and its low expression is a favorable prognostic marker in acute myeloid leukemia

BACKGROUND: Alterations of the short arm of chromosome 12 (12p) occur in various hematologic malignancies and ETV6 and CDKN1B, which are located on 12p, have been implicated as leukemogenic genes of interest. DESIGN AND METHODS: We selected seven patients with myeloid malignancies and small 12p dele...

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Bibliographic Details
Main Authors: Haferlach, Claudia, Bacher, Ulrike, Kohlmann, Alexander, Schindela, Sonja, Alpermann, Tamara, Kern, Wolfgang, Schnittger, Susanne, Haferlach, Torsten
Format: Artigo
Language:Inglês
Published: Ferrata Storti Foundation 2011
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105644/
https://ncbi.nlm.nih.gov/pubmed/21422114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.035584
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