Up-regulation of homeodomain genes, DLX1 and DLX2, by FLT3 signaling

BACKGROUND: Activating mutations in fms-like tyrosine kinase-3 (FLT3) are frequent in acute myeloid leukemia and represent both a poor prognostic feature and a therapeutic target. We have identified a previously unrecognized downstream effect of FLT3 activation, namely up-regulation of the homeodoma...

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Hauptverfasser: Starkova, Julia, Gadgil, Sharvari, Qiu, Yi Hua, Zhang, Nianxiang, Hermanova, Ivana, Kornblau, Steven M., Drabkin, Harry A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2011
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105643/
https://ncbi.nlm.nih.gov/pubmed/21357706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.031179
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