Promoter polymorphisms in the beta-2 adrenergic receptor are associated with drug-induced gene expression changes and response in acute lymphoblastic leukemia

We investigated whether genetic polymorphisms in the promoter region of the pro-apoptotic beta-2 adrenergic receptor gene (ADRB2) influence treatment-induced changes in ADRB2 expression in leukemia cells and response to chemotherapy. The ADRB2 promoter region was genotyped in germline DNA from 369 c...

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Autori principali: Pottier, N, Paugh, SW, Ding, C, Pei, D, Yang, W, Das, S, Cook, EH, Pui, C-H, Relling, MV, Cheok, MH, Evans, WE
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105596/
https://ncbi.nlm.nih.gov/pubmed/20981007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2010.212
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