The role of TP53 and MDM2 polymorphisms in TP53 mutagenesis and risk of non-melanoma skin cancer

P53 is a key regulatory molecule in the cellular response to ultraviolet radiation, and TP53 mutation is the most common alteration in non-melanoma skin cancer. The MDM2 oncogene negatively regulates p53 protein levels, and both genes have functional polymorphisms that may modify skin cancer risk. F...

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Autori principali: Almquist, Lindsay M., Karagas, Margaret R., Christensen, Brock C., Welsh, Marleen M., Perry, Ann E., Storm, Craig A., Nelson, Heather H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2011
Soggetti:
Molecular Epidemiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105583/
https://ncbi.nlm.nih.gov/pubmed/21123835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgq256
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