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JLK1486, a Bis 8-Hydroxyquinoline-Substituted Benzylamine, Displays Cytostatic Effects in Experimental Gliomas through MyT1 and STAT1 Activation and, to a Lesser Extent, PPARγ Activation

Gliomas account for 5% to 7% of all solid cancers in adults and up to 30% of solid cancers in children; glioblastomas are the most malignant type of glioma and often have dismal prognoses. The alkylating agent temozolomide provides the greatest chemotherapeutic benefits currently available; however,...

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Autors principals: Bruyère, Céline, Madonna, Sébastien, Van Goietsenoven, Gwendoline, Mathieu, Véronique, Dessolin, Jean, Kraus, Jean-Louis, Lefranc, Florence, Kiss, Robert
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press Inc. 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105292/
https://ncbi.nlm.nih.gov/pubmed/21633668
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