The binding of an antisense oligonucleotide to a hairpin structure via triplex formation inhibits chemical and biological reactions.
We have investigated the binding of a 26-mer antisense oligodeoxynucleotide to a 69-mer DNA hairpin with a 13 base pair stem, bearing an Rsa1 restriction site. The 5' part of the 26-mer annealed to a stretch of six purines at the bottom of the hairpin. The 3' part was designed to fold back to form a...
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| Publicado en: | Nucleic Acids Res |
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| Autores principales: | , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
1993
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| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310525/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8284206/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.24.5616 |
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