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Use of (18)O labels to monitor deamidation during protein and peptide sample processing
Nonenzymatic deamidation of asparagine residues in proteins generates aspartyl (Asp) and isoaspartyl (isoAsp) residues via a succinimide intermediate in a neutral or basic environment. Electron capture dissociation (ECD) can differentiate and quantify the relative abundance of these isomeric product...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3105245/ https://ncbi.nlm.nih.gov/pubmed/18394920 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jasms.2008.02.011 |
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