Inflammation Triggers Emergency Granulopoiesis through a Density-Dependent Feedback Mechanism

Normally, neutrophil pools are maintained by homeostatic mechanisms that require the transcription factor C/EBPα. Inflammation, however, induces neutrophilia through a distinct pathway of “emergency” granulopoiesis that is dependent on C/EBPβ. Here, we show in mice that alum triggers emergency granu...

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Bibliographic Details
Main Authors: Cain, Derek W., Snowden, Pilar B., Sempowski, Gregory D., Kelsoe, Garnett
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104996/
https://ncbi.nlm.nih.gov/pubmed/21655273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0019957
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