Inconsistent Protective Efficacy and Marked Polymorphism Limits the Value of Schistosoma japonicum Tetraspanin-2 as a Vaccine Target

BACKGROUND: Schistosoma mansoni tetraspanin 2 (Sm-TSP-2) has been shown to be strongly recognized by IgG1 and IgG3 antibodies from individuals putatively resistant to schistosome infection, but not chronically infected people, and to induce high levels of protection against challenge infection in th...

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Main Authors: Zhang, Wenbao, Li, Jun, Duke, Mary, Jones, Malcolm K., Kuang, Ling, Zhang, Jianfeng, Blair, David, Li, Yuesheng, McManus, Donald P.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104969/
https://ncbi.nlm.nih.gov/pubmed/21655308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001166
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