Preparation of trimers and tetramers of mixed sequence oligodeoxynucleoside methylphosphonates and assignment of configurations at the chiral phosphorus.

Synthesis of stereoregular DNA methylphosphonates has been accomplished for homo-oligomers, but remains a formidable problem for oligomers of a defined antisense target sequence. In this work, four trimer and tetramer deoxynucleoside methylphosphonates of mixed sequence (dACA, dCCAA, dAGGG, and dGCA...

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Опубликовано в: :Nucleic Acids Res
Главные авторы: Vyazovkina, E V, Rife, J P, Lebedev, A V, Wickstrom, E
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 1993
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310481/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8290358/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.25.5957
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