Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

The continued spread of the HIV epidemic underscores the need to interrupt transmission. One attractive strategy is a topical vaginal microbicide. Sexual transmission of herpes simplex virus type 2 (HSV-2) in mice can be inhibited by intravaginal siRNA application. To overcome the challenges of knoc...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Wheeler, Lee Adam, Trifonova, Radiana, Vrbanac, Vladimir, Basar, Emre, McKernan, Shannon, Xu, Zhan, Seung, Edward, Deruaz, Maud, Dudek, Tim, Einarsson, Jon Ivar, Yang, Linda, Allen, Todd M., Luster, Andrew D., Tager, Andrew M., Dykxhoorn, Derek M., Lieberman, Judy
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2011
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104760/
https://ncbi.nlm.nih.gov/pubmed/21576818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45876
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