Inhibition of HIV transmission in human cervicovaginal explants and humanized mice using CD4 aptamer-siRNA chimeras

The continued spread of the HIV epidemic underscores the need to interrupt transmission. One attractive strategy is a topical vaginal microbicide. Sexual transmission of herpes simplex virus type 2 (HSV-2) in mice can be inhibited by intravaginal siRNA application. To overcome the challenges of knoc...

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Autors principals: Wheeler, Lee Adam, Trifonova, Radiana, Vrbanac, Vladimir, Basar, Emre, McKernan, Shannon, Xu, Zhan, Seung, Edward, Deruaz, Maud, Dudek, Tim, Einarsson, Jon Ivar, Yang, Linda, Allen, Todd M., Luster, Andrew D., Tager, Andrew M., Dykxhoorn, Derek M., Lieberman, Judy
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104760/
https://ncbi.nlm.nih.gov/pubmed/21576818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45876
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