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Generating mouse models of degenerative diseases using Cre/lox-mediated in vivo mosaic cell ablation

Most degenerative diseases begin with a gradual loss of specific cell types before reaching a threshold for symptomatic onset. However, the endogenous regenerative capacities of different tissues are difficult to study, because of the limitations of models for early stages of cell loss. Therefore, w...

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Hlavní autoři: Fujioka, Masato, Tokano, Hisashi, Fujioka, Keiko Shiina, Okano, Hideyuki, Edge, Albert S.B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104751/
https://ncbi.nlm.nih.gov/pubmed/21576819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45081
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