Загрузка...

Autoimmunity in MFG-E8–deficient mice is associated with altered trafficking and enhanced cross-presentation of apoptotic cell antigens

Apoptotic cells must be rapidly cleared, as defects in this process can lead to autoimmunity. Milk fat globule EGF factor 8 (MFG-E8) binds to apoptotic cells and facilitates their removal through interaction with phagocytes. Mice deficient in MFG-E8 develop lupus-like autoimmunity associated with ac...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Peng, YuFeng, Elkon, Keith B.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2011
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104739/
https://ncbi.nlm.nih.gov/pubmed/21537078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI43254
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!