Bioengineered Human Arginase I with Enhanced Activity and Stability Controls Hepatocellular and Pancreatic Carcinoma Xenografts

Hepatocellular carcinoma (HCC) and pancreatic carcinoma (PC) cells often have inherent urea cycle defects rendering them auxotrophic for the amino acid l-arginine (l-arg). Most HCC and PC require extracellular sources of l-arg and undergo cell cycle arrest and apoptosis when l-arg is restricted. Sys...

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Autors principals: Glazer, Evan S, Stone, Everett M, Zhu, Cihui, Massey, Katherine L, Hamir, Amir N, Curley, Steven A
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press Inc. 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104694/
https://ncbi.nlm.nih.gov/pubmed/21633669
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