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Instability of the monofunctional adducts in cis-[Pt(NH3)2(N7-N-methyl-2-diazapyrenium)Cl](2+)-modified DNA: rates of cross-linking reactions in cis-platinum-modified DNA.

Single- and double-stranded oligonucleotides containing a single monofunctional cis-[Pt(NH3)2(dG)(N7-N-methyl-2-diazapyrenium)]3+ adduct have been studied at two NaCl concentrations. In 50 mM and 1 M NaCl, the adducts within the single-stranded oligonucleotides are stable. In contrast, they are unst...

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Détails bibliographiques
Auteurs principaux: Payet, D, Gaucheron, F, Sip, M, Leng, M
Format: Artigo
Langue:Inglês
Publié: 1993
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC310464/
https://ncbi.nlm.nih.gov/pubmed/8290343
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