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Design of Deinococcus radiodurans thioredoxin reductase with altered thioredoxin specificity using computational alanine mutagenesis

In this study, the X-ray crystal structure of the complex between Escherichia coli thioredoxin reductase (EC TrxR) and its substrate thioredoxin (Trx) was used as a guide to design a Deinococcus radiodurans TrxR (DR TrxR) mutant with altered Trx specificity. Previous studies have shown that TrxRs ha...

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Autores principales: Obiero, Josiah, Sanders, David AR
Formato: Artigo
Lenguaje:Inglês
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2011
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104231/
https://ncbi.nlm.nih.gov/pubmed/21465613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.635
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