Phase II Trial of Lapatinib and Topotecan (LapTop) in Patients with Platinum-Refractory/Resistant Ovarian and Primary Peritoneal Carcinoma

OBJECTIVE: Resistance to chemotherapy is a major challenge in the treatment of ovarian/peritoneal cancer. One purported mechanism of topotecan resistance is the breast cancer resistance protein (BCRP) and P-glycoprotein (Pgp). We designed a phase II clinical trial evaluating the efficacy and adverse...

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Main Authors: Weroha, S. John, Oberg, Ann L., Allen Ziegler, Katie L., Dakhilm, Shaker R., Rowland, Kendrith M., Hartmann, Lynn C., Moore, Dennis F., Keeney, Gary L., Peethambaram, Prema P., Haluska, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104066/
https://ncbi.nlm.nih.gov/pubmed/21514634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2011.03.030
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