Evaluation of Lapatinib and Topotecan Combination Therapy: Tissue Culture, Murine Xenograft, and Phase I Clinical Trial Data

PURPOSE: Topotecan resistance can result from drug efflux by P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) as well as survival signals initiated by epidermal growth factor receptor family members. The present studies were done to determine the effect of combining topotecan and the...

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Detalhes bibliográficos
Main Authors: Molina, Julian R., Kaufmann, Scott H., Reid, Joel M., Rubin, Stephen D., Gálvez-Peralta, Marina, Friedman, Robert, Flatten, Karen S., Koch, Kevin M., Gilmer, Tona M., Mullin, Robert J., Jewell, Roxanne C., Felten, Sara J., Mandrekar, Sumithra, Adjei, Alex A., Erlichman, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725396/
https://ncbi.nlm.nih.gov/pubmed/19047120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0415
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