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Glutamatergic Signaling Maintains the Epithelial Phenotype of Proximal Tubular Cells

Epithelial–mesenchymal transition (EMT) contributes to the progression of renal tubulointerstitial fibrosis. The N-methyl-d-aspartate receptor (NMDAR), which is present in proximal tubular epithelium, is a glutamate receptor that acts as a calcium channel. Activation of NMDAR induces actin rearrange...

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Autors principals: Bozic, Milica, de Rooij, Johan, Parisi, Eva, Ortega, Marta Ruiz, Fernandez, Elvira, Valdivielso, José M.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Nephrology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103729/
https://ncbi.nlm.nih.gov/pubmed/21597037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010070701
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