The Connexin40 A96S Mutation Causes Renin-Dependent Hypertension

Deletion of the gap-junction–forming protein connexin40 leads to renin-dependent hypertension in mice, but whether observed human variants in connexin40, such as A96S, promote hypertension is unknown. Here, we generated mice with the A96S variant in the mouse connexin40 gene. Although mice homozygou...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lübkemeier, Indra, Machura, Katharina, Kurtz, Lisa, Neubauer, Björn, Dobrowolski, Radek, Schweda, Frank, Wagner, Charlotte, Willecke, Klaus, Kurtz, Armin
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society of Nephrology 2011
Pynciau:
Basic Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103723/
https://ncbi.nlm.nih.gov/pubmed/21597036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010101047
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