PolyI:C Suppresses Acetaminophen-Induced Hepatotoxicity Independent of Type I Interferons and Toll-Like Receptor 3

Viral infections are often linked to altered drug metabolism in patients; however, the underlying molecular mechanisms remain unclear. Here, we describe a mechanism by which activation of anti-viral responses by the synthetic double stranded RNA ligand, polyinosinic-polycytidylic acid (polyI:C), lea...

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Bibliographic Details
Main Authors: Ghaffari, Amir A., Chow, Edward K., Iyer, Shankar S., Deng, Jane C., Cheng, Genhong
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103596/
https://ncbi.nlm.nih.gov/pubmed/21433044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24316
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