Bicistronic Lentiviruses Containing a Viral 2A Cleavage Sequence Reliably Co-Express Two Proteins and Restore Vision to an Animal Model of LCA1

The disease processes underlying inherited retinal disease are complex and are not completely understood. Many of the corrective gene therapies designed to treat diseases linked to mutations in genes specifically expressed in photoreceptor cells restore function to these cells but fail to stop progr...

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Main Authors: Verrier, Jonathan D., Madorsky, Irina, Coggin, William E., Geesey, Mero, Hochman, Michael, Walling, Elleanor, Daroszewski, Daniel, Eccles, Kristofer S., Ludlow, Rachel, Semple-Rowland, Susan L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103589/
https://ncbi.nlm.nih.gov/pubmed/21647387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020553
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