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Tyrosine phosphorylation of Munc18c on residue 521 abrogates binding to Syntaxin 4
BACKGROUND: Insulin stimulates exocytosis of GLUT4 from an intracellular store to the cell surface of fat and muscle cells. Fusion of GLUT4-containing vesicles with the plasma membrane requires the SNARE proteins Syntaxin 4, VAMP2 and the regulatory Sec1/Munc18 protein, Munc18c. Syntaxin 4 and Munc1...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3103433/ https://ncbi.nlm.nih.gov/pubmed/21548926 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2091-12-19 |
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