Tyrosine phosphorylation–dependent activation of TRPC6 regulated by PLC-γ1 and nephrin: effect of mutations associated with focal segmental glomerulosclerosis

Transient receptor potential canonicals (TRPCs) play important roles in the regulation of intracellular calcium concentration. Mutations in the TRPC6 gene are found in patients with focal segmental glomerulosclerosis (FSGS), a proteinuric disease characterized by dysregulated function of renal glome...

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Bibliographic Details
Main Authors: Kanda, Shoichiro, Harita, Yutaka, Shibagaki, Yoshio, Sekine, Takashi, Igarashi, Takashi, Inoue, Takafumi, Hattori, Seisuke
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103399/
https://ncbi.nlm.nih.gov/pubmed/21471003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-12-0929
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