Mislocalization of the E3 Ligase, β-Transducin Repeat-containing Protein 1 (β-TrCP1), in Glioblastoma Uncouples Negative Feedback between the Pleckstrin Homology Domain Leucine-rich Repeat Protein Phosphatase 1 (PHLPP1) and Akt

The PH domain leucine-rich repeat protein phosphatase, PHLPP, plays a central role in controlling the amplitude of growth factor signaling by directly dephosphorylating and thereby inactivating Akt. The cellular levels of PHLPP1 have recently been shown to be enhanced by its substrate, activated Akt...

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Detalles Bibliográficos
Autores principales: Warfel, Noel A., Niederst, Matt, Stevens, Michael W., Brennan, Paul M., Frame, Margaret C., Newton, Alexandra C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103356/
https://ncbi.nlm.nih.gov/pubmed/21454620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.237081
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