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Ibulocydine Is a Novel Prodrug Cdk Inhibitor That Effectively Induces Apoptosis in Hepatocellular Carcinoma Cells

Hepatocellular carcinoma (HCC) is frequently associated with abnormalities in cell cycle regulation, leading to increased activity of cyclin-dependent kinases (Cdks) due to the loss, or low expression of, Cdk inhibitors. In this study, we showed that ibulocydine (an isobutyrate prodrug of the specif...

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Main Authors: Cho, Seung-Ju, Kim, Young-Jong, Surh, Young-Joon, Kim, B. Moon, Lee, Seung-Ki
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103345/
https://ncbi.nlm.nih.gov/pubmed/21478145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.209551
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