The NLR Adaptor ASC/PYCARD Regulates DUSP10, Mitogen-activated Protein Kinase (MAPK), and Chemokine Induction Independent of the Inflammasome

ASC/PYCARD is a common adaptor for a diverse set of inflammasomes that activate caspase-1, most prominently the NLR-based inflammasome. Mounting evidence indicates that ASC and these NLRs also elicit non-overlapping functions, but the molecular basis for this difference is unclear. To address this,...

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Bibliographic Details
Main Authors: Taxman, Debra J., Holley-Guthrie, Elizabeth A., Huang, Max Tze-Han, Moore, Chris B., Bergstralh, Daniel T., Allen, Irving C., Lei, Yu, Gris, Denis, Ting, Jenny Pan-Yun
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103340/
https://ncbi.nlm.nih.gov/pubmed/21487011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.221077
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